Potential #Alzheimer’s medication shows promise in mouse model of neurodegenerative disease

Originally posted 2016-12-20 18:44:03.

Memory loss and other cognitive symptoms of Alzheimer’s disease are attributed, in part, to the degeneration of acetylcholine-producing neurons. Acetylcholinesterase inhibitors are a common treatment for patients with Alzheimer’s; however, in spite of their clinical benefits, these non-selective medications are also associated with numerous adverse effects. It has been hypothesized that more selective targeting of acetylcholine signaling may reduce the side effects associated with current Alzheimer’s medications, but it’s not known whether improving selectivity could decrease the treatment’s efficacy.Memory loss and other cognitive symptoms of Alzheimer’s disease are attributed, in part, to the degeneration of acetylcholine-producing neurons. Acetylcholinesterase inhibitors are a common treatment for patients with Alzheimer’s; however, in spite of their clinical benefits, these non-selective medications are also associated with numerous adverse effects. It has been hypothesized that more selective targeting of acetylcholine signaling may reduce the side effects associated with current Alzheimer’s medications, but it’s not known whether improving selectivity could decrease the treatment’s efficacy.

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