Nanotechnology Tool Allows Detailed Study of Proteins in Living Cells | #Alzheimer

Originally posted 2016-06-16 15:42:41.


Scientists from Massachusetts General Hospital (MGH) and the Rowland Institute at Harvard University have used a specialized nanoprobe developed by the Harvard/Rowland investigators to measure levels of key proteins directly within living, cultured cells. As described in Nano Letters (“Direct Tracking of Amyloid and Tau Dynamics in Neuroblastoma Cells Using Nanoplasmonic Fiber Tip Probes”), the investigators used the device to track levels of the Alzheimer’s-disease-associated proteins amyloid-β (Aβ) and tau in neurons and other cells exposed to an anesthetic known to produce Alzheimer’s-like changes in the brains of mice. Their results support the view that the generation of Aβ is among the first steps leading to the characteristic neurodegeneration of Alzheimer’s disease.

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